JOURNAL OF CHILEAN CHEMICAL SOCIETY

Vol 66 No 2 (2021): Journal of the Chilean Chemical Society
Original Research Papers

SYNTHESIS OF 6-TERT-OCTYL AND 6,8-DITERT-BUTYL COUMARINS, TWO COUMARINS OF BIOLOGICAL INTEREST

Miguel Zárraga Olavarría
Universidad de Concepción
Mohamed Dahrouch
Universidad de Concepción
Bio
Esteban Lisboa
Universidad de Concepción
Bio
Patricia Arroyo
Universidad de Concepción
Bio
Alberto Miranda
Universidad Metropolitana de Ciencias de la Educación
Bio
Published June 13, 2021
Keywords
  • COUMARINS,
  • hydrophobic,
  • TRPV1
How to Cite
Zárraga Olavarría, M., Dahrouch, M., Lisboa, E., Arroyo, P., & Miranda, A. (2021). SYNTHESIS OF 6-TERT-OCTYL AND 6,8-DITERT-BUTYL COUMARINS, TWO COUMARINS OF BIOLOGICAL INTEREST. Journal of the Chilean Chemical Society, 66(2), 5220-5222. Retrieved from https://www.jcchems.com/index.php/JCCHEMS/article/view/1740

Abstract

In this study, the synthesis of new coumarins with aliphatic chains is discussed. The incorporation of the 6-tert-octyl and 6,8-ditert-butyl chains into a coumarin structure from alkylphenols, allows obtaining hydrophobic coumarins with good yields. These coumarins can be potential modulators of TRPV1 receptors. Synthesis and spectroscopic data of these new coumarins are analyzed.

 

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