JOURNAL OF CHILEAN CHEMICAL SOCIETY

Vol 61 No 2 (2016): Journal of the Chilean Chemical Society
Original Research Papers

SYNTHESIS AND STUDY ON MAGNETIC RESONANCE IMAGING PERFORMANCE OF GD(III)-DTPABISBENZOTHIAZOL HYDRAZIDE

Fu-Xian Wan
College of Chemistry and Material Science, Shan Dong Agricultural University, Taian 271018, People’s Republic of China
Tian-Kai Zhang
College of Chemistry and Material Science, Shan Dong Agricultural University, Taian 271018, People’s Republic of China
Ying Li
College of Chemistry and Material Science, Shan Dong Agricultural University, Taian 271018, People’s Republic of China
Chang-Cheng Li
College of Chemistry and Material Science, Shan Dong Agricultural University, Taian 271018, People’s Republic of China
Lin Jiang
College of Chemistry and Material Science, Shan Dong Agricultural University, Taian 271018, People’s Republic of China
Vol 61, No 2 (2016): Journal of the Chilean Chemical Society
Published June 10, 2016
Keywords
  • MRI contrast agent,
  • Benzothiazole,
  • DTPA derivative,
  • Gadolinium complex,
  • Relaxivity
How to Cite
Wan, F.-X., Zhang, T.-K., Li, Y., Li, C.-C., & Jiang, L. (2016). SYNTHESIS AND STUDY ON MAGNETIC RESONANCE IMAGING PERFORMANCE OF GD(III)-DTPABISBENZOTHIAZOL HYDRAZIDE. Journal of the Chilean Chemical Society, 61(2). Retrieved from https://www.jcchems.com/index.php/JCCHEMS/article/view/3

Abstract

In this paper, 2-hydrazino-6-methoxy-1,3-benzothiazole was introduced into diethylenetriamine pentaacetic ( DTPA) by acylation reaction. The correspond­ing non-ion Gd(III) complex holding promise of a single molecule magnetic resonance imaging (MRI) contrast agent was obtained by treating this ligand with GdCl3·6h2 O. The efficacy of the contrast agent was assessed by measuring the longitudinal relaxivity (r1), the r1 of Gd(III)-DTPA-bisbenzothiazole hydrazide was up to 6.44 mM-1·s-1, which was 1.8 times higher than that of the analogous MRI contrast agent Gd(III)-DTPA(r1 = 3.64 mM-1·s-1) in commercial use. In addition, in vitro MR images on a 0.5 T magnetic field exhibited a remarkable enhancement of signal contrast for Gd(III)-DTPA-bisbenzothiazole hydrazide than Gd(III)-DTPA. These results demonstrate that this non-ion Gd(III) complex acts as a potentially MRI contrast agent.

Scheme 1. Synthesis of ligand(H3L) and complex(Gd(III)-L)

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