JOURNAL OF CHILEAN CHEMICAL SOCIETY

Vol 65 No 1 (2020): Journal of the Chilean Chemical Society
Original Research Papers

SYNTHESIS AND CHARACTERIZATION OF GADOLINIUM-BASED NANOCRYSTALS FOR THEIR POTENTIAL APPLICATION AS TRIMODAL IMAGING CONTRAST AGENTS

Haroon ur Rashid
Dr. Haroon-Ur-Rashid, Postdoctoral fellow, School of Chemistry & Chemical Engineering, Guangxi University, Nanning, China Email: haroongold@gmail.com
Bio
Muhammad yaseen
Institute of Chemical Sciences, University of Peshawar, Peshawar, Khyber Pakhtunkhwa, Pakistan
Ali Riaz
Department of Chemistry, Sarhad University of Science & Information Technology, Peshawar, Khyber Pakhtunkhwa, Pakistan
Published March 17, 2020
Keywords
  • lanthanide,
  • nanocrystals,
  • trimodal,
  • gadolinium,
  • contrast agents

Abstract

Abstract

Lanthanide-doped gadolinium nanomaterials have attracted considerable attention due to their promising applications in biological imaging. Sodium gadolinium fluoride (β-NaGdF4) nanomaterials act as perfect host for doping of luminescent lanthanide ions. Due to heavy nature of gadolinium, it can strongly absorb X-ray radiations. Therefore, Gd-based nanomaterials are applied as contrast agents for X-ray tomography (CT). Presence of seven unpaired electrons in Gd+3 ion, its large magnetic moment and long electronic relaxation time makes it an ideal candidate to enhance water proton relaxation rates. These characteristics make Gd-based nanomaterial useful for their potential application as MRI contrast agents. In this work, sodium gadolinium fluoride is doped with ytterbiumand erbium to produce β-NaGdF4:Yb/Er as core nanocrystals. They are subsequently coated with sodium gadolinium fluoride doped with neodymium (β-NaGdF4:Nd) to produce β-NaGdF4:Yb/Er@β-NaGdF4:Nd core-shell nanocrystals. Powder X‐ray diffraction (XRD) results indicated that β-NaGdF4 (host), β-NaGdF4:Yb/Er (core) and β-NaGdF4:Yb/Er@β-NaGdF4:Nd (core-shell) nanocrystals all exist in hexagonal crystalline phase. While Dynamic Light Scattering (DLS) results indicated that the particle size of the synthesized nanocrystals was in range of 12 to 27 nm. FTIR results confirmed that the synthesized nanocrystals were stabilized by oleic acid. Nanocrystals reported in this work are expected to be useful trimodal contrast agents for photoluminescence, X-ray tomography and Magnetic Resonance Imaging (MRI).

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