JOURNAL OF CHILEAN CHEMICAL SOCIETY

Vol 61 No 2 (2016): Journal of the Chilean Chemical Society
Original Research Papers

NEW SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF MIRTAZAPINE IN PHARMACEUTICAL FORMULATIONS

Fozia Rehman
aInterdisciplinary Research Centre in Biomedical Materials(IRCBM) COMSATS Institute of Information Technology, Lahore
Saima Gul
Department of Chemistry University of Swabi for Woman Gulo-Deri, Swabi, KPK
Sajjad Hussain
Faculty of Materials & Chemical Engineering GIK Institute of Engineering Sciences & Technology Topi, KPK
Sabir khan
UNESP – Universidade Estadual Paulista, Institute of Chemistry, Department of Analytical Chemistry 14801-970, Araraquara
Vol 61, No 2 (2016): Journal of the Chilean Chemical Society
Published June 10, 2016
Keywords
  • Spectrophotometric,
  • Ion-association,
  • Pharmaceutical formulations
How to Cite
Rehman, F., Gul, S., Hussain, S., & khan, S. (2016). NEW SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF MIRTAZAPINE IN PHARMACEUTICAL FORMULATIONS. Journal of the Chilean Chemical Society, 61(2). Retrieved from https://www.jcchems.com/index.php/JCCHEMS/article/view/14

Abstract

A simple extractive spectrophotometric method has been developed for the quantification of mirtazapine. This method is based on the formation of ion-association complex of mirtazapine drug with bromocresol purple dye. The absorbance of the complex was measured at 400 nm. The method was successfully applied to the determination of mirtazapine in their pharmaceutical formulations. The method shows a linear range from 0.2-10 μg mL-1 with a molar absorptivity of 1.53 ‘104 L mol-1 cm-1. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 0.096 μg mL-1 and 0.32μg mL-1 respectively. The developed methodology was successfully applied for the determination of mirtazapine in commercial formulation and the percentage recovery was found 99.91 ± 0.15. The developed methodology promises a feasible, low cost and an efficient method for the routine analysis.

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