JOURNAL OF CHILEAN CHEMICAL SOCIETY

Vol 62 No 1 (2017): Journal of the Chilean Chemical Society
Original Research Papers

SYNTHESIS, QUALITY CONTROL AND BIODISTRIBUTION OF TECHNEIUM-99M TRIAMCINOLONE ACETONIDE (99mTc-TA) COMPLEX: AN INFLAMMATION TRACER AGENT

PDF
  • Faheem Askari Rizvi,
  • Syed Ali Raza Naqvi,
  • Muhammad Mehdi,
  • Samina Roohi,
  • Ameer Fawad Zahoor,
  • Zulfiqar Ali Khan,
  • Muhammad Sohaib,
  • Rashid Rasheed
Faheem Askari Rizvi
Department of Chemistry, Government College University Faisalabad
Syed Ali Raza Naqvi
Department of Chemistry, Government College University Faisalabad
Muhammad Mehdi
Department of Chemistry, Government College University Faisalabad
Samina Roohi
Isotope Production Division, Pakistan Institute of Nuclear Science and Technology
Ameer Fawad Zahoor
Department of Chemistry, Government College University Faisalabad
Zulfiqar Ali Khan
Department of Chemistry, Government College University Faisalabad
Muhammad Sohaib
Department of Medical Sciences, Pakistan Institute of Engineering and Applied Sciences, (PIEAS)
Rashid Rasheed
Department of Chemistry, Government College University Faisalabad Institute of Nuclear Oncology and Radiology (INOR)
Published June 5, 2017
Keywords
  • 99mTc-Triamcinolone,
  • Electrophoresis,
  • Biodistribution study,
  • Scintigraphy of Rabbits,
  • Serum Stability
How to Cite
Askari Rizvi, F., Raza Naqvi, S. A., Mehdi, M., Roohi, S., Fawad Zahoor, A., Khan, Z. A., Sohaib, M., & Rasheed, R. (2017). SYNTHESIS, QUALITY CONTROL AND BIODISTRIBUTION OF TECHNEIUM-99M TRIAMCINOLONE ACETONIDE (99mTc-TA) COMPLEX: AN INFLAMMATION TRACER AGENT. Journal of the Chilean Chemical Society, 62(1). Retrieved from https://www.jcchems.com/index.php/JCCHEMS/article/view/145

Copyright (c) 2017 Faheem Askari Rizvi, Syed Ali Raza Naqvi, Muhammad Mehdi, Samina Roohi, Ameer Fawad Zahoor, Zulfiqar Ali Khan, Muhammad Sohaib, Rashid Rasheed

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Abstract

In present study synthesis of 99mTc-triamcinolone acetonide (99mTc-TA) complex and its stability using set of quality control parameters such as ligand con­centration, reducing agent concentration, pH, temperature and reaction time was assessed. 99mTc-TA complex was characterized in terms of percent (%) yield, stability in saline and serum using chromatographic procedures. Radiochemically the 99mTc-TA complex was found quite stable in saline and serum. After 30 min of reaction the complex showed maximum radiochemical yield of 96.32% which decreased to 96.25 % after 4 h incubation period. In serum, the % yield of radio­chemical was remained same up to 2 h which decreased to 93.5% at 24 h time point. Normal biodistribution pattern in Sprague-Dawley rats revealed liver, stomach and kidneys as areas of high 99mTc-TA complex uptake (8.44 ± 1.32, 8.75 ± 1.03 and 12.67 ± 1.21%, respectively) at 1 h post injection time point. Scintigraphy of 99mTc-TA in rabbits showed similar eco as observed in biodistribution study. Based on the promising results obtained in context of in vitro and in vivo stability and biodistribution, 99mTc-TA complex could be further studied to identify the inflammation based diseases.

PDF

References

  1. K. E. Britton, S. Vinjamuri, A. V. Hall, K. Solanki, Q. H. Siraj, J. Bomanji, S. Das. Eur. J. Nucl. Med. 24, 553, (1997).
  2. S. A. R. Naqvi, M. M. Ishfaq, Z. A. Khan, S. A. Nagra, I. H. Bukhari, A. I. Hussain, N. Mahmood, S. A. Shahzad, A. Haque, T. H. Bokhari. Turk. J. Chem. 36, 267, (2012).
  3. M. S. Akhtar, M. B. Imran, M. A. Nadeem, A. Shahid. Intern. J. Pept., 2012, 19, (2012).
  4. M. M. Welling, G. Ferro-Flores, I. Pirmettis, C. P. J. Brouwer, M. Anti-In¬fect. Agent. Med. Chem. 8, 272, (2009).
  5. S. Vinjamuri, K. K. Solanki, J. Bomanji, Q. Siraj, K. E. Britton, A. V. Hall, E. O’Shaughnessy, S. S. Das, Lancet. 347, 233 (1996).
  6. K. Sonmezoglu, M. Sonmezoglu, M. Halac, I. Akgün, C. Türkmen, C. Önsel, B. Kanmaz, K. Solanki, K. E. Britton, I. Uslu, J. Nucl. Med. 42, 567, (2001).
  7. A.; Doroudi, M.; Erfani, F.; Kooshki, S. M.; Saadati, F.; Ahmadi, A.; Ki¬asat, M. J.; Khodayar, B.; Etessami, H. Meghdadi, Iran. J. Nucl. Med., 23, 96, (2015).
  9. X. Wang, D. Li, W. Deuther-Conrad, J. Lu, Y. Xie, B. Jia, M. Cui, J. Stein¬bach, P. Brust, B. Liu, et al., J. Med. Chem. 57, 7113 (2014).
  10. J. Barbet, M. Bardies, M. Bourgeois, J. F. Chatal, M. Cherel, F. Davodeau, A. Faivre-Chauvet, J. F. Gestin, F. Kraeber-Bodere, Meth. Mol. Biol., 907, 681, (2012).
  12. A. Frilling, F. Weber, V. Cicinnati, C. Broelsch, Exp. Rev. Endocr.Metab., 2, 517, (2007).
  13. S. A. R. Naqvi, T. Matzow, C. Finucane, S. A. Nagra, M. M. Ishfaq, S. J. Mather, J. Sosabowski, Cancer. Biother. Radiopharm., 25, 89, (2010).
  14. A. M. Peters, Semin. Nucl. Med., 24, 110, (1994).
  15. D. K. Hughes, J. Nucl. Med. Technol., 31, 196, (2003).
  17. G. Gerasimou, E. Moralidis, E. Papanastasiou, G. Liaros, T. Aggelopou¬lou, E. Triantafyllidou, N. Lytras, L. Settas, A.Gotzamani-Psarrakou, Hip¬pokratia., 15, 37, (2011).
  18. M. S. Akhtar, J. Iqbal, M. A. Khan, J. Irfanullah, M. Jehangir, B. Khan, I. Ul-Haq, G. Muhammad, M. A. Nadeem, M. S Afzal, et al., J. Nucl. Med., 45, 849, (2004).
  19. C. Love, C. J. Palestro, J. Nucl. Med. Technol., 32, 47, (2004).
  20. K. E. Britton, D. W. Wareham, S. S. Das, K. K. Solanki, H. Amaral, A. Bhatnagar, A. H. Katamihardja, J. Malamitsi, H. M. Moustafa, V. E So¬roa,.et al., J. Clin. Pathol., 55, 817, (2002).
  22. L. Sarda, A. C. Cremieux, Y. Lebellec, A. Meulemans, R. Lebtahi, G. Hayem, R. Genin, N. Delahaye, D. Huten, D. Le Guludec, J. Nucl. Med., 44, 920, (2003).
  23. A. Kaul, P. P. Hazari, H. Rawat, B. Singh, T. C. Kalawat, S. Sharma, A. K. Babbar, A. K. Mishra, Int. J. Infect. Diseas. 17, e263, (2013).
  24. A. T. Kay, D. M. Bolt, A. Ishihara, P. J. Rajala-Schultz, A. L. Bertone, Am. J. Vet. Res., 69, 1646, (2008)
  25. O. Uckermann, F. Kutzera, A. Wolf, T. Pannicke, A. Reichenbach, P. Wi¬edemann, S. Wolf, Bringmann, A. J. Pharmac. Exper. Therap., 315, 1036, (2005).
  26. X. Zhang, S. Bao, D. Lai, R. W. Rapkins, M. C. Gillies, Diabetes., 57, 1026, (2008).
  27. D. K. Nayak, R. Baishya, K. K. Halder, T. Sen, B. R. Sarkar, S. Ganguly, M. K. Das, M. C. Debnath, Metallomics., 4, 1197, (2012).

Copyright @2019 | Designed by: Open Journal Systems Chile Logo Open Journal Systems Chile Support OJS, training, DOI, Indexing, Hosting OJS

Code under GNU license: OJS PKP