JOURNAL OF CHILEAN CHEMICAL SOCIETY

Vol 61 No 2 (2016): Journal of the Chilean Chemical Society
Original Research Papers

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL PROPERTIES OF NEW CODEINE FE(III) COMPLEX

Shahriar Ghamami
Department of Chemistry, Faculty of Science, Imam Khomeini International University, Qazvin 34148-96818
Mojdeh Golzani
Department of Chemistry, Faculty of Science, Imam Khomeini International University, Qazvin 34148-96818
Amir Lashgari
Department of Chemistry, Faculty of Science, Imam Khomeini International University, Qazvin 34148-96818
Vol 61, No 2 (2016): Journal of the Chilean Chemical Society
Published June 10, 2016
Keywords
  • Codeine,
  • Fe(III) complex,
  • Synthesis,
  • Anti-tumor,
  • AGS and MCF-7,
  • Antibacterial
  • ...More
    Less

Abstract

The reaction of FeCl3hexahydrate with C18H20NO3.PO4 in acetonitrile produced new complex with general formula [Fe(L)]Cl2, (L= codeine). Characterization of the ligand and its complex were made by elemental analysis, FT-IR, 1H-NMR, Raman and UV–visible spectroscopy. This new complex showed antitumor activity against two kinds of cancer cell lines: AGS (Stomach) and MCF-7 (Breast). Cell cytotoxic effects of the ligand and its complex were assayed by MTT and Natural-red tests. The antibacterial activity of ligand and complex against Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus pyogenes and Escherichia coli were also examined.

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