- Neonicotinoids,
- nicotinic acetylcholine receptors,
- synthetic pesticides
Copyright (c) 2023 SChQ
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Abstract
Neonicotinoid compounds have been used as insecticides since the 1990s to effectively control Hemipteran pests such as aphids, leafhoppers, whiteflies, and additionally, for their lethal activity and low toxicity in humans. The synthesis of novel neonicotinoids compounds was achieved using (S)-(-)-(1-methyl-2-pyrrolidinyl)methanol and (±)-2-(1-methyl-2-pyrrolidinyl)ethanol with nitrobenzoyl chlorides derivatives in diethyl ether at room temperature to concentrate in vacuum to subsequently neutralize (pH = 8) with 7.4% (w/v) isopropanol HCl solution to obtain hydrochloride salts. (S)-(1-methyl-2-pyrrolidinyl)methyl and (±)-2-(1-methyl-2-pyrrolidinyl)ethyl 2-nitrobenzoate salts was not possible to form.
References
- Malhotra, N. et al. Int J Mol Sci. 22, 9591, (2021).
- Millar, N. S. & Denholm, I. Invertebrate Neuroscience. 7, 53–66, (2007).
- Zhang, D. & Lu, S. Environment International vol. 163, (2022).
- Buszewski, B., Bukowska, M., Ligor, M. & Staneczko-Baranowska, I. Environmental Science and Pollution Research vol. 26 34723–34740, (2019).
- Costas-Ferreira, C. & Faro, L. R. F. Int J Mol Sci. 22, 8413, (2021).
- Lu, X. et al. Molecules. 27, (2022).
- Lu, S. et al. J Agric Food Chem. 60, 322–330, (2012).
- Bonilla-Landa, I. et al. J Agric Food Chem. 69, 1455–1465, (2021).
- Kimura-Kuroda, J. et al. Int J Environ Res Public Health. 13, 987 (2016).
- Houchat, J. N., Cartereau, A., Le Mauff, A., Taillebois, E. & Thany, S. H. International Journal of Environmental Research and Public Health. 17, (2020).
- Grünewald, B. & Siefert, P. Insects. 10, 420 (2019).
- Cartereau, A., Taillebois, E., Le Questel, J.-Y. & Thany, S. H. Int J Mol Sci. 22, 9880 (2021).
- Faundez-Parraguez, M. et al. Bioorg Med Chem. 21, 2687–2694, (2013).
- ffrench-Constant, R. H., Williamson, M. S., Davies, T. G. E. & Bass, C. J Neurogenet. 30, 163–177, (2016).
- Viscarra, F. et al. Molecules. 25, 2998, (2020).
- Gonzalez-Gutierrez, J. P. et al. Molecules. 24, 2684, (2019).
- González-Gutiérrez, J. P. et al. Molecules. 24, 3808, (2019).
- Gálvez, G. et al. Biomedicines. 10, 1482, (2022).
- Bass, C. et al. Insect Biochem Mol Biol. 51, 41–51, (2014).
- Margaritopoulos, J. T., Kati, A. N., Voudouris, C. Ch., Skouras, P. J. & Tsitsipis, J. A. Bull Entomol Res. 111, 1–16, (2021).
