JOURNAL OF CHILEAN CHEMICAL SOCIETY

Vol 61 No 2 (2016): Journal of the Chilean Chemical Society
Original Research Papers

THE EFFECT OF DIFFERENT RETINA DISEASES ON CHOLESTEROL AND FATTY ACID CONTENT OF SILICONE OIL FROM VITRECTOMIZED EYES

Hulya Güngel
Istanbul Training and Research Hospital, Clinic of Ophthalmology, Fatih, 34098 Istanbul
Serife Evrim Kepekci Tekkeli
Bezmialem Vakif University, Faculty of Pharmacy, Department of Analytical Chemistry, Fatih, 34093 Istanbul
Vol 61, No 2 (2016): Journal of the Chilean Chemical Society
Published June 10, 2016
Keywords
  • Fatty acids,
  • FTIR,
  • Silicone,
  • Epoxigenases
How to Cite
Güngel, H., & Kepekci Tekkeli, S. E. (2016). THE EFFECT OF DIFFERENT RETINA DISEASES ON CHOLESTEROL AND FATTY ACID CONTENT OF SILICONE OIL FROM VITRECTOMIZED EYES. Journal of the Chilean Chemical Society, 61(2). Retrieved from https://www.jcchems.com/index.php/JCCHEMS/article/view/28

Abstract

The differences of cholesterol and fatty acid content of silicone oils that were removed from vitrectomized eyes due to different retinal diseases were investigated. The silicone oils were removed from 25 cases after 4-8 months and classified in two groups; Group A consists of 11 patients who had undergone pars plana vitrectomy combined with phacoemulsification and intraocular lens implantation due to diabetic tractional retinal detachment and Group B consists of 14 patients who was treated for phakic primary rhegmatogenous retinal detachment. The removed material from vitrectomized eyes in Group A was opacified and gelatinous on the other hand in Group B it was transparent. Hexan extracts were prepared from liquid and emulsified phases. The extracts were taken into vials, after that, hexane was removed. The chemical structure of each extracted material was investigated by spectroscopic techniques. The concentration of unsaturated fatty acids (FAs) in both groups were compared statistically. In conclusion, in Group A, epoxy and hydroxy-epoxy FAs were determined. The mean amount of unsaturated FAs in Group A was significantly lower than Group B. Cholesterol was not detected in any samples. The type of FAs in removed silicone oils may differ depending on the oxidative stress of retina.

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