JOURNAL OF CHILEAN CHEMICAL SOCIETY

Vol 62 No 3 (2017): Journal of the Chilean Chemical Society
Original Research Papers

A REVIEW OF RAMAN, SURFACE-ENHANCED RAMAN SCATTERING (SERS) AND RELATED SPECTROSCOPIC TECHNIQUES APPLIED TO BIOMOLECULES IN BIOMATERIALS

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  • Freddy Celis,
  • Macarena Garcia,
  • Guillermo Diaz-Fleming,
  • Marcelo Campos-Vallette
Freddy Celis
Laboratorio de Espectroscopía Vibracional Aplicada, Departamento de Química y Centro de Estudios Avanzados (CEA), Universidad de Playa Ancha Laboratorio de Espectroscopía Vibracional, Departamento de Química, Universidad de Chile
Macarena Garcia
Laboratorio de Polímeros Conductores, Departamento de Química de los Materiales, Facultad de Química y Biología, Universidad de Santiago de Chile
Guillermo Diaz-Fleming
Laboratorio de Espectroscopía Atómica y Molecular, CESPAM, Departamento de Química, Universidad de Playa Ancha
Marcelo Campos-Vallette
Laboratorio de Espectroscopía Vibracional, Departamento de Química, Universidad de Chile
Published September 2, 2017
Keywords
  • Raman,
  • SERS,
  • Biomolecules,
  • Biomaterials,
  • Nanoparticles
How to Cite
Celis, F., Garcia, M., Diaz-Fleming, G., & Campos-Vallette, M. (2017). A REVIEW OF RAMAN, SURFACE-ENHANCED RAMAN SCATTERING (SERS) AND RELATED SPECTROSCOPIC TECHNIQUES APPLIED TO BIOMOLECULES IN BIOMATERIALS. Journal of the Chilean Chemical Society, 62(3). Retrieved from https://www.jcchems.com/index.php/JCCHEMS/article/view/324

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Abstract

The development of new biomaterials has gained increasing attention in the last decade. One of the most important aspects in the development of these new materials is to understand the chemical cues presents in the native niche. Among all the techniques currently available for measuring those interactions, Raman spectroscopy offers a unique and non-invasive tool for exploring the behavior of the components within a given biomaterial and their surrounding microenvironment. This technique exploits the unique molecular vibrational fingerprints for pinpointing those interactions. The vibrational response can be improved to the single molecule level, in the presence of metal nanoparticles (NPs) with plasmonic properties (silver, gold and copper) in the so-called Surface- Enhanced Raman Scattering (SERS), which can be used for in-situ measurements. Another technique recently developed is the Shell-Isolated Nanoparticle- Enhanced Raman Spectroscopy (SHINERS), which overcomes signal contamination from chemical interactions between biomolecules and the metal surface; it does this by coating the metal surface with an inert layer of alumina or silica. In the present contribution, the role and the applications of Raman, SERS and related spectroscopic techniques in the study of biomolecules in biomaterials are reviewed and discussed.

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