JOURNAL OF CHILEAN CHEMICAL SOCIETY

Vol 63 No 2 (2018): Journal of the Chilean Chemical Society
Original Research Papers

FACILE ECOFRIENDLY ONE POT SYNTHESIS OF HETEROCYCLIC PRIVILEDGED MEDICINAL SCAFFOLDS VIA BIGINELLI REACTION USING RETRIEVABLE NICKEL NANOPARTICLES AS CATALYST

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  • Dhivya Paul,
  • Ramanjaneya Reddy Gontu,
  • Subramanian Parameswaran Rajendran
Dhivya Paul
Department of Chemistry, School of Chemical Sciences, Bharathiar University
Ramanjaneya Reddy Gontu
Department of Inorganic Chemistry, School of Chemical Sciences, University of Madras, Guindy Campus
Subramanian Parameswaran Rajendran
Department of Chemistry, School of Chemical Sciences, Bharathiar University
Published June 25, 2018
Keywords
  • Nickel (II) exchanged zeolite [Ni(II)Y],
  • Biginelli reaction,
  • microwave irradiation,
  • green condition,
  • human pathogens,
  • DPPH radical scavenging activity
    • ...More
    Less
How to Cite
Paul, D., Reddy Gontu, R., & Parameswaran Rajendran, S. (2018). FACILE ECOFRIENDLY ONE POT SYNTHESIS OF HETEROCYCLIC PRIVILEDGED MEDICINAL SCAFFOLDS VIA BIGINELLI REACTION USING RETRIEVABLE NICKEL NANOPARTICLES AS CATALYST. Journal of the Chilean Chemical Society, 63(2). Retrieved from https://www.jcchems.com/index.php/JCCHEMS/article/view/681

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Abstract

An efficient and greener synthesis of a series of dihydropyrimidone (DHPMs)/ dihydropyrimithione (DHPMTs) derivatives were accomplished via three component one pot condensation between quinoline aldehyde (2-hydroxy-4-formyl quinoline/2-formyl-4-methoxy quinoline) , β – keto ester (ethyl acetoacetate / methyl acetoacetate) and urea/ thiourea using nickel(II) exchanged zeolite [Ni(II)Y] (NiNPs). The NiNPs were characterized by Infrared spectroscopy, Powder X ray diffraction patterns, Electronic microscopy studies- Scanning Electron Microscopy (FESEM) and Transmission Electron Microscopy (TEM). After the course of the reaction, the NiNPs were recovered and reused without any apparent loss of activity. The newly synthesized compounds were screened for antimicrobial activity against two human bacterial pathogens, the Gram-positive Methicillin resistant Staphylococcus aureus (MRSA) and the Gram-negative Pseudomonas aeruginosa (MTCC 201) and a human yeast pathogen, Fluconazole resistant Candida albicans (FRCA). The synthesised compounds were also evaluated for their antioxidant activity and the compounds show significant scavenging activity compared to aspartic acid.

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