JOURNAL OF CHILEAN CHEMICAL SOCIETY

Vol 61 No 3 (2016): Journal of the Chilean Chemical Society
Original Research Papers

SIMULTANEOUS DETERMINATION OF SACCHARINE, CAFFEINE, SALICYLIC ACID AND BENZOIC ACID IN DIFFERENT MATRIXES BY SALT AND AIR-ASSISTED HOMOGENEOUS LIQUID-LIQUID EXTRACTION AND HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY

Rouhollah Heydari
Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences
Masoumeh Mousav
Department of Chemistry, Payame Noor Universtiy
Published September 10, 2016
Keywords
  • Homogeneous liquid-liquid extraction,
  • Salt and air-assisted,
  • Saccharine,
  • Caffeine,
  • Salicylic acid,
  • Benzoic acid,
  • High-performance liquid chromatography
  • ...More
    Less

Abstract

Saccharine, caffeine, salicylic acid and benzoic acid were extracted and quantified simultaneously by coupling the salt and air-assisted homogeneous liquid-liquid extraction (SAAHLLE) technique with high-performance liquid chromatography (HPLC). Various parameters such as extraction solvent and its volume, salt and its concentration, volume of injected air, vortex time and sample pH were evaluated and optimized. Analytical parameters of the proposed method were determined under the optimized conditions. The calibration curves showed good linearity in the range of 5-100 μg/mL for saccharine, caffeine, salicylic acid and benzoic acid. The limit of detection (LOD) values for saccharine, caffeine, salicylic acid and benzoic acid were 0.024, 0.013, 0.0048 and 0.0052 ng/mL, respectively. The recoveries were in the range of 88.0–94.0% with RSD values ranging from 3.8 to 6.8%. 

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