JOURNAL OF CHILEAN CHEMICAL SOCIETY

Vol 61 No 3 (2016): Journal of the Chilean Chemical Society
Original Research Papers

DEVELOPMENT OF A KINETIC SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF CICLOPIROX OLAMINE IN PHARMACEUTICAL SAMPLE

Fallon Nacaratte
Department of Chemistry, Faculty of Sciences, University of Chile
M. Inés Toral
Department of Chemistry, Faculty of Sciences, University of Chile
César Soto
Department of Analytical and Inorganic Chemistry, Faculty of Chemical Sciences, University of Concepción
Published September 10, 2016
Keywords
  • Kinetic,
  • Spectrophotometric,
  • Ciclopirox olamine
How to Cite
Nacaratte, F., Toral, M. I., & Soto, C. (2016). DEVELOPMENT OF A KINETIC SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF CICLOPIROX OLAMINE IN PHARMACEUTICAL SAMPLE. Journal of the Chilean Chemical Society, 61(3). Retrieved from https://www.jcchems.com/index.php/JCCHEMS/article/view/87

Abstract

A simple and sensitive kinetic spectrophotometric method was developed for the determination of ciclopirox olamine in pharmaceutical formulations (cream). The method is based on the oxidation of ciclopirox olamine with KMnO4 in alkaline medium to form K2MnO4, a bluish green color compound, at ionic strength controlled and room temperature. The reaction is monitored measuring the rate of change of absorbance at 610 nm. The absorbance-concentration plot corresponding to synthetic pharmaceutical samples (cream) was rectilinear, over the range of 0.32 – 10.0 μg mL-1, with detection and quantification limits of 0.095 μg mL-1 and 0.32 μg mL-1, respectively. Different experimental parameters affecting the development and stability of the reaction product were carefully studied via factorial screening and optimized by univariate method. The determination of ciclopirox olamine by the fixed time method is feasible and more advantageous with the calibration equation obtained at 30 min. The proposed method was validated for the application of the determination of the drug in pharmaceutical sample (cream). 

References

  1. A.K. Gupta, A.R. Skinner, Int. J. Dermatol. 42, 3, (2003).
  2. Subissi A, Monti D, Togni G, Mailland F. Drugs. 70, 2133, (2010).
  3. Junmei Li, Ye Jiang, Ting Sun, Shumeng Ren. J. of Pharma., and Biome. Anal. 47, 929, (2008).
  4. www.drugs.com/ciclopirox/ciclopirox-olamine.html
  5. M. Niewerth, D. Kunze, B. Hube, Antimicrobial Agents and Chemotherapy 47 (6), 1805, (2003).
  6. United States Pharmacopoeia 28, NF23, Convention, Inc., Rockville, MD, 470, (2005).
  7. United States Pharmacopoeia 25, NF 20. Convention, Rockville, MD, 418, (2002).
  8. K.H. Lehr, P. Damn, J. Chromatogr. B Biomed. Sciences and Appl. 339, 451, (1985).
  9. L. Gagliardi, G. Multari, G. Cavazzutti, D. Tonelli, J. Liq. Chromatogr. Relat. Technol. 21, 2365, (1998).
  10. A. Escarrone, C. Bittencourt, E. Primel, S. Caldas. Chromatographia, 67, 967, (2008).
  11. F. Belliardo, A. Bertolino, G. Brandolo and C. Lucarelli. J. of Chromatography A 553, 41, (1991).
  12. M. Ibrahim Walash, M. Salem Rizk, M. Ibrahim Eid, M. el Sayed Fathy. Acta Pharm. 56, 431, (2006).
  13. L. Ferreira, F. Fabiana and A. Lucio, Electroanalysis 24, 961, (2012).
  14. F. Ibrahim, N. El-Enany. J. of Pharma., and Biomed. Anal. 32, 353, (2003).
  15. F. Ibrahim, N. El-Enany. Il Farmaco 58, 1313, (2003).
  16. Junmei Li, Ye Jiang, Ting Sun, Shumeng Ren, Journal of Pharmaceutical and Biomedical Analysis 47, 929, (2008).
  17. F. Silva, F. Claudimir, L. do Lago and L. Angnes, Electrophoresis, 32, 900, (2011).
  18. Wei Bu, Xiaoqing Fan, H. Sexton and I. Heyman, J. of Pharma. and Biomed. Anal. 51, 230, (2010).
  19. Ayad M et al., European Journal of Chemistry, 4, 35, (2013).
  20. Abdellaziz L. and Hosny M., Analytical Chemistry Insights, 6, 67, (2011).
  21. A. Espinosa-Mansilla, M. Valenzuela, F. Salinas, Canada. F. Anal. Chim. Acta., 376, 193, (1998).
  22. Khalil Farhadi and Hossein Sheikhloei Bonab J. Chin. Chem. Soc., 51, 743, (2004).
  23. Oxidation in organic chemistry, Wiber K., Part A, Academic press New York, 17, (1965).
  24. Rose, J. in Advanced Physicochemical Experiments, Pitman, London, UK, 67, (1964).
  25. G. Theodoridisa, E. H. M. Kosterb and G. J. de Jong. J. of Chromatography B 745, 49, (2000).
  26. Fábio R. and P. Rocha. Quim. Nova, 27, 807, (2004).
  27. HandBook of Pharmaceutical Excipients 6th ed., Rowe R., Sheskey P. and Quinn M., APHA, 2009.

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